Your browser doesn't support javascript.
Show: 20 | 50 | 100
Results 1 - 3 de 3
Filter
1.
J Transl Med ; 20(1): 270, 2022 06 15.
Article in English | MEDLINE | ID: covidwho-1902395

ABSTRACT

BACKGROUND: Heart failure (HF) is a global leading cause of mortality despite implementation of guideline directed therapy which warrants a need for novel treatment strategies. Proof-of-concept clinical trials of anakinra, a recombinant human Interleukin-1 (IL-1) receptor antagonist, have shown promising results in patients with HF. METHOD: We designed a single center, randomized, placebo controlled, double-blind phase II randomized clinical trial. One hundred and two adult patients hospitalized within 2 weeks of discharge due to acute decompensated HF with reduced ejection fraction (HFrEF) and systemic inflammation (high sensitivity of C-reactive protein > 2 mg/L) will be randomized in 2:1 ratio to receive anakinra or placebo for 24 weeks. The primary objective is to determine the effect of anakinra on peak oxygen consumption (VO2) measured at cardiopulmonary exercise testing (CPX) after 24 weeks of treatment, with placebo-corrected changes in peak VO2 at CPX after 24 weeks (or longest available follow up). Secondary exploratory endpoints will assess the effects of anakinra on additional CPX parameters, structural and functional echocardiographic data, noninvasive hemodynamic, quality of life questionnaires, biomarkers, and HF outcomes. DISCUSSION: The current trial will assess the effects of IL-1 blockade with anakinra for 24 weeks on cardiorespiratory fitness in patients with recent hospitalization due to acute decompensated HFrEF. TRIAL REGISTRATION: The trial was registered prospectively with ClinicalTrials.gov on Jan 8, 2019, identifier NCT03797001.


Subject(s)
Heart Failure , Adult , Double-Blind Method , Humans , Interleukin 1 Receptor Antagonist Protein/pharmacology , Interleukin 1 Receptor Antagonist Protein/therapeutic use , Interleukin-1 , Quality of Life , Stroke Volume/physiology , Treatment Outcome
2.
Frontiers in Marine Science ; 2022.
Article in English | ProQuest Central | ID: covidwho-1622576

ABSTRACT

Editorial on the Research Topic Fish Nutrition, Metabolism and Physiology Aquatic foods from marine and freshwater play a significant role in nutrition of billions of people globally, particularly during the COVID-19 pandemic which has jeopardized the global food security (Tigchelaar et al., 2021). [...]aquatic foods are considered as unique and rich sources of n-3 long-chain polyunsaturated fatty acids (LC-PUFA) such as EPA and DHA with beneficial impacts in a range of human pathologies particularly cardiovascular diseases (Golden et al., 2021). [...]promoting intestinal health of fish fed high soybean meal diets through supplementation of bioactive compounds has also drawn increasing attention. [...]the inclusion of higher plant are often associated with research challenges for fish health and welfare. [...]identifying LC-PUFA biosynthesis in fish fed plant oils has pivotal implication for aquafeeds formulation.

SELECTION OF CITATIONS
SEARCH DETAIL